Pyrrolo[1,2-a]pyrazin-1(2H)-one

Name: Pyrrolo[1,2-a]pyrazin-1(2H)-one
Brand: ChemScene
Availability: InStock
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CAS No. 136927-63-4
Cat. No. CS-0044055
Purity≥97%
MDL No.MFCD09834911

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Pyrrolo[1,2-a]pyrazin-1(2H)-one|CS-0044055

Structure of 136927-63-4

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General Information

CAS No. 136927-63-4
Cat. No. CS-0044055
Purity ≥97%
MDL No. MFCD09834911
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆N₂O
Molecular Weight 134.14
Synonym(s) Pyrrolo[1,2-a]pyrazin-1(2H)-one (9CI)
SMILES O=C1C2=CC=CN2C=CN1

Description

Pyrrolo[1,2-a]pyrazin-1(2H)-one features a fused heterocyclic core with intrinsic electron-rich character, enabling robust participation in transition-metal-catalyzed couplings. This bench-stable scaffold integrates readily into complex molecular architectures, offering enhanced solubility and compatibility across synthetic workflows.

Application

Pyrrolo[1,2-a]pyrazin-1(2H)-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to nitrogen-rich scaffolds through established functionalization protocols. Its inherent stability and compatibility with diverse reaction conditions facilitate downstream derivatization, including C–H activation and transition-metal-catalyzed couplings. The scaffold demonstrates robust performance in solid-phase synthesis and solution-phase transformations, making it a reliable component for drug discovery campaigns targeting kinase inhibitors and other bioactive molecules.

Synthesis

Route1
- In-stock
  
  4513-94-4
- ~%
- In-stock
  
  136927-63-4
References
- WO2007/38387 A2, ; Page/Page column 80 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 37.27
LogP 0.6276
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

Key Words

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Pyrrolo[1,2-a]pyrazin-1(2H)-one

CAS No. 136927-63-4

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