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CS-W001157 4
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5-Aminonicotinonitrile

  • CAS No. 13600-47-0

  • Cat. No. CS-W003368
  • Purity≥97%
  • MDL No.MFCD07367907

*For research and further manufacturing use only, not for direct human use.

5-Aminonicotinonitrile|CS-W003368

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General Information

  • CAS No. 13600-47-0
  • Cat. No. CS-W003368
  • Purity ≥97%
  • MDL No. MFCD07367907
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅N₃
  • Molecular Weight 119.12
  • Synonym(s) 5-Amino-3-pyridinecarbonitrile
  • SMILES Nc1cc(cnc1)C#N

Description

5-Aminonicotinonitrile features a bifunctional scaffold combining an electron-rich amine and a strongly electron-deficient nitrile group. This arrangement enables direct incorporation into diverse heterocyclic systems via nucleophilic addition or coupling reactions. The molecule exhibits robust bench stability and compatibility with standard synthetic protocols, facilitating efficient access to functionalized pyridine derivatives for medicinal chemistry applications.

Application

5-Aminonicotinonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of pyridine-based heterocycles and bioactive scaffolds. Its dual functionality—amine and nitrile groups—supports diverse transformations including amidation, cyclization, and metal-catalyzed coupling reactions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   62.7
  • LogP   0.53548
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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