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CS-W001157 4
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5-Amino-6-methylnicotinonitrile

  • CAS No. 3308-01-8

  • Cat. No. CS-W007092
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Amino-6-methylnicotinonitrile|CS-W007092

Structure of 3308-01-8

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General Information

  • CAS No. 3308-01-8
  • Cat. No. CS-W007092
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇N₃
  • Molecular Weight 133.15
  • Synonym(s) 5-Amino-6-methyl-nicotinonitrile
  • SMILES N#CC1=CN=C(C)C(N)=C1

Description

5-Amino-6-methylnicotinonitrile features a pyridine core functionalized with an amino group at C5, a methyl substituent at C6, and a nitrile at C3. This electron-rich scaffold enables efficient coupling in synthetic sequences, particularly in medicinal chemistry applications requiring polar, rigid heterocyclic motifs. The compound exhibits favorable solubility and stability under standard conditions.

Application

5-Amino-6-methylnicotinonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard functional group manipulations. Its amino and nitrile groups offer orthogonal reactivity for derivatization, while the methyl substituent enhances metabolic stability. The compound exhibits bench stability and compatibility with common coupling and cyclization protocols, facilitating efficient synthesis of pyridine-based scaffolds relevant to pharmaceutical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   62.7
  • LogP   0.8439
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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