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Bis(1,1-dimethylethyl)[4-methoxy-3,5,6-trimethyl-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine

  • CAS No. 1359986-21-2

  • Cat. No. CS-0035179
  • Purity≥98%
  • MDL No.MFCD22666028

*For research and further manufacturing use only, not for direct human use.

Bis(1,1-dimethylethyl)[4-methoxy-3,5,6-trimethyl-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine|CS-0035179

Structure of 1359986-21-2

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General Information

  • CAS No. 1359986-21-2
  • Cat. No. CS-0035179
  • Purity ≥98%
  • MDL No. MFCD22666028
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₃H₅₃OP
  • Molecular Weight 496.75
  • Synonym(s) Me3(OMe)tBuXPhos
  • SMILES CC1=C(C)C(C2=C(C(C)C)C=C(C(C)C)C=C2C(C)C)=C(P(C(C)(C)C)C(C)(C)C)C(C)=C1OC

Description

Bis(1,1-dimethylethyl)[4-methoxy-3,5,6-trimethyl-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine is a sterically hindered, electron-rich phosphine featuring a bulky biphenyl backbone and methoxy substitution. This configuration enhances stability and solubility in organic media while maintaining high reactivity in palladium-catalyzed cross-coupling processes under standard conditions.

Application

Bis(1,1-dimethylethyl)[4-methoxy-3,5,6-trimethyl-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine serves as a sterically hindered, electron-rich phosphine ligand that enables efficient transition-metal-catalyzed cross-coupling reactions. Its robust steric bulk and functional group tolerance facilitate stable catalyst formation, enhancing reactivity in palladium- and nickel-catalyzed transformations. The ligand exhibits excellent bench stability and simplifies purification in complex synthetic sequences.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   10.3619
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   6

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