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CS-W001157 4
Total: USD 88.00

(2-(Difluoromethoxy)-6-fluorophenyl)methanamine hydrochloride

  • CAS No. 1354951-46-4

  • Cat. No. CS-0103458
  • Purity≥95%
  • MDL No.MFCD20731225

*For research and further manufacturing use only, not for direct human use.

(2-(Difluoromethoxy)-6-fluorophenyl)methanamine hydrochloride|CS-0103458

Structure of 1354951-46-4

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General Information

  • CAS No. 1354951-46-4
  • Cat. No. CS-0103458
  • Purity ≥95%
  • MDL No. MFCD20731225
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉ClF₃NO
  • Molecular Weight 227.61
  • Synonym(s) 2-(Difluoromethoxy)-6-fluorobenzyl amine HCl
  • SMILES NCC1=C(F)C=CC=C1OC(F)F.[H]Cl

Description

This difluoromethoxy-substituted aniline derivative features a hydrochloride salt form that enhances solubility and stability. The para-fluoro and ortho-difluoromethoxy groups confer electron-withdrawing character, enabling effective integration into pharmaceutical intermediates and bioactive molecule scaffolds under standard conditions.

Application

(2-(Difluoromethoxy)-6-fluorophenyl)methanamine hydrochloride serves as a valuable building block for the synthesis of fluorinated aromatic amines, enabling efficient access to bioactive scaffolds in medicinal chemistry. Its difluoromethoxy and fluorophenyl functionalities provide enhanced metabolic stability and modulated lipophilicity. The hydrochloride salt ensures excellent bench stability, ease of handling, and straightforward purification, facilitating its use in standard amine coupling, electrophilic substitution, and heterocycle construction workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.3076
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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