(2-Fluoro-6-methoxyphenyl)methanamine hydrochloride

Name: (2-Fluoro-6-methoxyphenyl)methanamine hydrochloride
Brand: ChemScene
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CAS No. 1214366-31-0
Cat. No. CS-0150325
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(2-Fluoro-6-methoxyphenyl)methanamine hydrochloride|CS-0150325

Structure of 1214366-31-0

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General Information

CAS No. 1214366-31-0
Cat. No. CS-0150325
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₁ClFNO
Molecular Weight 191.63
Synonym(s) (2-Fluoro-6-methoxyphenyl)-methylamine hydrochloride
SMILES COC1=CC=CC(F)=C1CN.Cl

Description

This bench-stable amine features a fluorinated aromatic ring paired with a methoxy group, enabling enhanced metabolic stability and tunable lipophilicity. The hydrochloride salt form ensures high solubility in aqueous media and simplifies handling in synthetic workflows. Ideal for incorporating into bioactive scaffolds requiring electron-withdrawing substituents and polar functionality.

Application

(2-Fluoro-6-methoxyphenyl)methanamine hydrochloride serves as a versatile building block for medicinal chemistry, enabling the synthesis of bioactive arylamines via standard amine coupling and electrophilic substitution reactions. The ortho-fluoro and para-methoxy substituents provide enhanced metabolic stability and modulate electronic properties, while the hydrochloride salt ensures excellent bench stability and ease of handling. This compound facilitates efficient access to heterocyclic scaffolds and drug-like intermediates through well-established synthetic protocols.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 35.25
LogP 1.7148
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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(2-Fluoro-6-methoxyphenyl)methanamine hydrochloride

CAS No. 1214366-31-0

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