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CS-W001157 4
Total: USD 88.00

(2-(Difluoromethoxy)-6-fluorophenyl)methanamine hydrochloride

  • CAS No. 1354951-46-4

  • Cat. No. CS-0103458
  • Purity≥95%
  • MDL No.MFCD20731225
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(2-(Difluoromethoxy)-6-fluorophenyl)methanamine hydrochloride|CS-0103458

Structure of 1354951-46-4

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Description

This difluoromethoxy-substituted aniline derivative features a hydrochloride salt form that enhances solubility and stability. The para-fluoro and ortho-difluoromethoxy groups confer electron-withdrawing character, enabling effective integration into pharmaceutical intermediates and bioactive molecule scaffolds under standard conditions.

Application

(2-(Difluoromethoxy)-6-fluorophenyl)methanamine hydrochloride serves as a valuable building block for the synthesis of fluorinated aromatic amines, enabling efficient access to bioactive scaffolds in medicinal chemistry. Its difluoromethoxy and fluorophenyl functionalities provide enhanced metabolic stability and modulated lipophilicity. The hydrochloride salt ensures excellent bench stability, ease of handling, and straightforward purification, facilitating its use in standard amine coupling, electrophilic substitution, and heterocycle construction workflows.

General Information

  • CAS No. 1354951-46-4
  • Cat. No. CS-0103458
  • Purity ≥95%
  • MDL No. MFCD20731225
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉ClF₃NO
  • Molecular Weight 227.61
  • Synonym(s) 2-(Difluoromethoxy)-6-fluorobenzyl amine HCl
  • SMILES NCC1=C(F)C=CC=C1OC(F)F.[H]Cl

Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.3076
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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