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Structure of 1354792-76-9
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This difluoromethyl-substituted azetidine hydrochloride delivers a strained, electron-deficient heterocyclic core ideal for medicinal chemistry applications. The trifluoromethyl-like electronic profile enhances metabolic stability and membrane permeability. Bench-stable and moisture-tolerant, it integrates seamlessly into synthetic routes requiring polar, bioactive scaffolds with improved pharmacokinetic properties.
3-(Difluoromethyl)azetidine hydrochloride serves as a versatile building block for medicinal chemistry, enabling direct incorporation of a difluoromethyl group into bioactive scaffolds. Its azetidine core provides enhanced metabolic stability and improved membrane permeability, while the difluoromethyl moiety offers favorable lipophilicity and electronic effects. The hydrochloride salt ensures excellent bench stability, ease of handling, and compatibility with standard synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: