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3-(Difluoromethyl)azetidine hydrochloride

  • CAS No. 1354792-76-9

  • Cat. No. CS-0051694
  • Molecule weight143.56
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(Difluoromethyl)azetidine hydrochloride|CS-0051694

Structure of 1354792-76-9

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General Information

  • CAS No. 1354792-76-9
  • Cat. No. CS-0051694
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈ClF₂N
  • Molecular Weight 143.56
  • Synonym(s) 3-(Difluoromethyl)azetidine HCl
  • SMILES Cl.FC(F)C1CNC1

Description

This difluoromethyl-substituted azetidine hydrochloride delivers a strained, electron-deficient heterocyclic core ideal for medicinal chemistry applications. The trifluoromethyl-like electronic profile enhances metabolic stability and membrane permeability. Bench-stable and moisture-tolerant, it integrates seamlessly into synthetic routes requiring polar, bioactive scaffolds with improved pharmacokinetic properties.

Application

3-(Difluoromethyl)azetidine hydrochloride serves as a versatile building block for medicinal chemistry, enabling direct incorporation of a difluoromethyl group into bioactive scaffolds. Its azetidine core provides enhanced metabolic stability and improved membrane permeability, while the difluoromethyl moiety offers favorable lipophilicity and electronic effects. The hydrochloride salt ensures excellent bench stability, ease of handling, and compatibility with standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   0.8927
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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