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Methyl 1H-pyrrolo[3,2-c]pyridine-3-carboxylate

  • CAS No. 1353101-49-1

  • Cat. No. CS-0043713
  • Purity≥97%
  • MDL No.MFCD21090431

*For research and further manufacturing use only, not for direct human use.

Methyl 1H-pyrrolo[3,2-c]pyridine-3-carboxylate|CS-0043713

Structure of 1353101-49-1

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General Information

  • CAS No. 1353101-49-1
  • Cat. No. CS-0043713
  • Purity ≥97%
  • MDL No. MFCD21090431
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂O₂
  • Molecular Weight 176.17
  • Synonym(s) 1H-Pyrrolo[3,2-c]pyridine-3-carboxylic acid Methyl ester
  • SMILES O=C(C1=CNC2=C1C=NC=C2)OC

Description

Methyl 1H-pyrrolo[3,2-c]pyridine-3-carboxylate features a fused heterocyclic core with a strategically positioned ester group, enabling direct incorporation into diverse synthetic sequences. The pyrrolopyridine scaffold imparts enhanced electron density and planarity, facilitating efficient coupling reactions. This bench-stable compound serves as a key intermediate in the development of bioactive molecules, particularly within kinase inhibitor and CNS-targeted drug discovery programs.

Application

Methyl 1H-pyrrolo[3,2-c]pyridine-3-carboxylate serves as a versatile heterocyclic building block for medicinal chemistry and materials science. Its pyrrolopyridine core enables efficient functionalization at the C3 position via palladium-catalyzed cross-coupling, while the ester group supports selective reduction or derivatization. Bench-stable and readily purified by chromatography, it functions as a key scaffold in the synthesis of kinase inhibitors and other bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   54.98
  • LogP   1.3495
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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