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Methyl 6-chloro-1H-pyrrolo[3,2-c]pyridine-3-carboxylate

  • CAS No. 1784502-69-7

  • Cat. No. CS-0162831
  • Molecule weight210.62
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 6-chloro-1H-pyrrolo[3,2-c]pyridine-3-carboxylate|CS-0162831

Structure of 1784502-69-7

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General Information

  • CAS No. 1784502-69-7
  • Cat. No. CS-0162831
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇ClN₂O₂
  • Molecular Weight 210.62
  • Synonym(s) 1H-Pyrrolo[3,2-c]pyridine-3-carboxylic acid, 6-chloro-, methyl ester
  • SMILES O=C(C1=CNC2=C1C=NC(Cl)=C2)OC

Description

Methyl 6-chloro-1H-pyrrolo[3,2-c]pyridine-3-carboxylate is a bench-stable heterocyclic ester featuring a chlorinated pyrrolopyridine core. This electron-deficient scaffold integrates readily into cross-coupling reactions and serves as a key intermediate in medicinal chemistry for constructing bioactive nitrogen-containing frameworks.

Application

Methyl 6-chloro-1H-pyrrolo[3,2-c]pyridine-3-carboxylate serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyrrolopyridine-based scaffolds. The chloro substituent at the 6-position facilitates palladium-catalyzed cross-coupling reactions, while the ester group supports selective reduction or hydrolysis. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for medicinal chemistry campaigns and process-scale applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   54.98
  • LogP   2.0029
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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