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CS-W001157 4
Total: USD 88.00

5-Formylfuran-2-carboxylic acid

  • CAS No. 13529-17-4

  • Cat. No. CS-W005879
  • Purity≥97%
  • MDL No.MFCD00020924

*For research and further manufacturing use only, not for direct human use.

5-Formylfuran-2-carboxylic acid|CS-W005879

Structure of 13529-17-4

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General Information

  • CAS No. 13529-17-4
  • Cat. No. CS-W005879
  • Purity ≥97%
  • MDL No. MFCD00020924
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄O₄
  • Molecular Weight 140.09
  • Synonym(s) Furfural-5-carboxylic Acid
  • SMILES O=CC=1OC(=CC1)C(=O)O

Description

5-Formylfuran-2-carboxylic acid features a conjugated diacid scaffold with a reactive aldehyde at the 5-position, enabling direct coupling in heterocyclic synthesis. The electron-deficient furan ring enhances electrophilicity for nucleophilic additions. This bifunctional moiety integrates readily into complex molecular architectures under mild conditions, offering streamlined access to functionalized heterocycles and bioactive intermediates.

Application

5-Formylfuran-2-carboxylic acid serves as a versatile di-functional building block for heterocyclic synthesis, enabling direct access to fused and substituted furan scaffolds. Its orthogonal reactivity—where the aldehyde group undergoes nucleophilic addition and the carboxylic acid supports coupling reactions—facilitates efficient diversification in medicinal chemistry and materials science. The compound exhibits excellent bench stability and is readily purified by recrystallization, making it well-suited for scalable synthetic workflows.

Synthesis

  • Route1
    • 5-Hydroxymethylfurfural, ≥99%|CS-1268396
      67-47-0
    • ~84%
    • In-stock
      5-Formylfuran-2-carboxylic acid|CS-W005879
      13529-17-4

    References

    • Mei, Zhen-Wu; Ma, Li-Jian; Kawafuchi, Hiroyuki; Okihara, Takumi; Inokuchi, Tsutomu Bulletin of the Chemical Society of Japan, 2009 , vol. 82, # 8 p. 1000 - 1002
  • Route2
    • 5-Hydroxymethylfurfural, ≥99%|CS-1268396
      67-47-0
    • ~7%
    • In-stock
      2,5-Furandicarboxaldehyde|CS-M0775
      823-82-5
    • In-stock
      5-Formylfuran-2-carboxylic acid|CS-W005879
      13529-17-4
    • 2,5-Furandicarboxylic acid,99.99%|CS-1709659
      3238-40-2

    References

    • Journal of Catalysis, , vol. 299, p. 316 - 320
  • Route3
    • 5-Hydroxymethylfurfural, ≥99%|CS-1268396
      67-47-0
    • ~21%
    • In-stock
      5-Formylfuran-2-carboxylic acid|CS-W005879
      13529-17-4
    • 2,5-Furandicarboxylic acid,99.99%|CS-1709659
      3238-40-2

    References

    • Green Chemistry, , vol. 15, # 8 p. 2240 - 2251

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   67.51
  • LogP   0.7903
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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