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CS-W001157 4
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Diethyl furan-2,5-dicarboxylate

  • CAS No. 53662-83-2

  • Cat. No. CS-0151761
  • Purity≥98%
  • MDL No.MFCD00449457

*For research and further manufacturing use only, not for direct human use.

Diethyl furan-2,5-dicarboxylate|CS-0151761

Structure of 53662-83-2

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General Information

  • CAS No. 53662-83-2
  • Cat. No. CS-0151761
  • Purity ≥98%
  • MDL No. MFCD00449457
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂O₅
  • Molecular Weight None
  • Synonym(s) 2,5-ethyl 2,5-furandicarboxylate
  • SMILES CCOC(=O)C1=CC=C(C(=O)OCC)O1

Description

Diethyl furan-2,5-dicarboxylate serves as a versatile diester scaffold for constructing heterocyclic architectures. The furan core imparts electron-rich character, enabling efficient participation in cycloaddition and transition-metal-catalyzed coupling reactions. This bench-stable reagent integrates readily into synthetic sequences requiring planar, conjugated intermediates with predictable reactivity profiles under standard conditions.

Application

Diethyl furan-2,5-dicarboxylate serves as a versatile synthon in heterocyclic synthesis, enabling efficient access to functionalized furan derivatives via standard ester manipulations. Its conjugated diester framework facilitates Diels-Alder reactions and transition-metal-catalyzed couplings, while exhibiting good bench stability and ease of purification. Functions effectively in the construction of bioactive scaffolds and advanced intermediates for pharmaceutical development.

Synthesis

  • Route1
    • 2,5-Furandicarboxylic acid,99.99%|CS-1709659
      3238-40-2
    • null|null
      64-17-5
    • ~96%
    • In-stock
      Diethyl furan-2,5-dicarboxylate|CS-0151761
      53662-83-2

    References

    • SUeD-CHEMIE AG; FRANKE, Oliver; RICHTER, Oliver Patent: WO2012/101015 A1, 2012 ; Location in patent: Page/Page column 19-20 ;
  • Route2
    • null|null
      64-17-5
    • null|null
      91547-65-8
    • ~%
    • 2,5-Furandicarboxylic acid,99.99%|CS-1709659
      3238-40-2
    • 5-(Ethoxycarbonyl)furan-2-carboxylic acid|CS-0318089
      32933-01-0
    • In-stock
      Diethyl furan-2,5-dicarboxylate|CS-0151761
      53662-83-2

    References

    • WO2013/49711 A1, ; Paragraph 0265; 0266: 0267; 0268 ;
  • Route3
    • null|null
      99173-84-9
    • ~%
    • In-stock
      Diethyl furan-2,5-dicarboxylate|CS-0151761
      53662-83-2

    References

    • DE850751 , ; Justus Liebigs Annalen der Chemie, , vol. 571, p. 44,55

Safety Information

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GHS Pictogram : N/A
GHS No : N/A
Signal Word : N/A
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

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Computational Chemistry Data

  • TPSA   65.74
  • LogP   1.633
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   4

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