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CS-W001157 4
Total: USD 88.00

5-Chloropyrazolo[1,5-a]pyridine-3-carboxylic acid

  • CAS No. 1352396-54-3

  • Cat. No. CS-0160673
  • Purity≥97%
  • MDL No.MFCD20660614

*For research and further manufacturing use only, not for direct human use.

5-Chloropyrazolo[1,5-a]pyridine-3-carboxylic acid|CS-0160673

Structure of 1352396-54-3

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General Information

  • CAS No. 1352396-54-3
  • Cat. No. CS-0160673
  • Purity ≥97%
  • MDL No. MFCD20660614
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClN₂O₂
  • Molecular Weight 196.59
  • Synonym(s) None
  • SMILES O=C(C1=C2C=C(Cl)C=CN2N=C1)O

Description

5-Chloropyrazolo[1,5-a]pyridine-3-carboxylic acid is a heterocyclic building block featuring a chlorinated pyrazolopyridine core fused with a carboxylic acid group. This scaffold integrates electron-deficient aromatic character with a polar functional handle, enabling direct conjugation in medicinal chemistry and materials science applications. The molecule exhibits enhanced stability under standard conditions and facilitates efficient derivatization via amide or ester formation.

Application

5-Chloropyrazolo[1,5-a]pyridine-3-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyrazolo[1,5-a]pyridine scaffolds prevalent in medicinal chemistry. The carboxylic acid group facilitates direct derivatization via amide coupling or esterification, while the chloro substituent supports palladium-catalyzed cross-coupling reactions. Its bench-stable solid form and compatibility with standard reaction conditions make it well-suited for iterative synthetic workflows in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   54.6
  • LogP   1.6859
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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