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CS-W001157 4
Total: USD 88.00

2-Methoxy-5-methylpyridine

  • CAS No. 13472-56-5

  • Cat. No. CS-W003554
  • Molecule weight123.15
  • Purity≥98%
  • MDL No.MFCD08703669

*For research and further manufacturing use only, not for direct human use.

2-Methoxy-5-methylpyridine|CS-W003554

Structure of 13472-56-5

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General Information

  • CAS No. 13472-56-5
  • Cat. No. CS-W003554
  • Purity ≥98%
  • MDL No. MFCD08703669
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NO
  • Molecular Weight 123.15
  • Synonym(s) Pyridine, 2-methoxy-5-methyl-
  • SMILES CC1=CN=C(OC)C=C1

Description

2-Methoxy-5-methylpyridine is a bench-stable, electron-rich heterocycle featuring complementary methoxy and methyl substituents at ortho positions relative to the nitrogen. This configuration enhances solubility in organic media while maintaining thermal resilience. The molecule serves as a pivotal scaffold for ligand design, pharmaceutical intermediates, and functional materials, enabling efficient coupling under standard cross-coupling conditions.

Application

2-Methoxy-5-methylpyridine serves as a versatile building block in medicinal chemistry, offering a well-defined pyridine scaffold with orthogonal functional handles. The methoxy group enables electrophilic substitution or Suzuki coupling under standard conditions, while the methyl substituent provides a site for directed ortho-metalation or oxidation to carboxylic acid derivatives. Bench-stable and amenable to purification via flash chromatography, it functions reliably in multistep syntheses of bioactive heterocycles and API intermediates.

Synthesis

  • Route1
    • In-stock
      2-Bromo-5-methylpyridine|CS-W007353
      3510-66-5
    • null|null
      124-41-4
    • ~91%
    • In-stock
      2-Methoxy-5-methylpyridine|CS-W003554
      13472-56-5

    References

    • MEUDT, Andreas; Rausch, Bernhard J. Patent: US2008/71084 A1, 2008 ; Location in patent: Page/Page column 4 ;
  • Route2

    References

    • Jaber, Nimer; Schumann, Herbert; Blum, Jochanan Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 4 p. 565 - 567
  • Route3
    • null|null
      108-99-6
    • ~%
    • In-stock
      2-Methoxy-5-methylpyridine|CS-W003554
      13472-56-5
    • 2-Methoxy-3-methylpyridine|CS-0153433
      19230-59-2

    References

    • Tetrahedron Letters, , vol. 31, # 5 p. 775 - 776

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.39862
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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