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5-Ethynyl-2-methoxypyridine

  • CAS No. 663955-59-7

  • Cat. No. CS-0050494
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Ethynyl-2-methoxypyridine|CS-0050494

Structure of 663955-59-7

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General Information

  • CAS No. 663955-59-7
  • Cat. No. CS-0050494
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇NO
  • Molecular Weight 133.15
  • Synonym(s) Pyridine, 5-ethynyl-2-methoxy- (9CI)
  • SMILES COC1=CC=C(C=N1)C#C

Description

5-Ethynyl-2-methoxypyridine is a bench-stable, moisture-tolerant pyridine derivative featuring a terminal alkyne group and a methoxy substituent. This combination enables efficient copper-catalyzed coupling reactions, facilitating the integration of diverse molecular architectures in synthetic organic chemistry and medicinal discovery workflows.

Application

5-Ethynyl-2-methoxypyridine serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to substituted pyridine scaffolds. Its terminal alkyne functionality facilitates Sonogashira and Glaser-type couplings with high chemoselectivity, while the 2-methoxy group provides mild electronic modulation and orthogonality in multi-step syntheses. The compound exhibits excellent bench stability and is readily purified by standard chromatographic methods, making it well-suited for iterative synthetic workflows in medicinal chemistry and materials science applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.0715
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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