3-Chloro-5-(2,2,2-trifluoroethoxy)pyridazine

Name: 3-Chloro-5-(2,2,2-trifluoroethoxy)pyridazine
Brand: ChemScene
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CAS No. 1346691-33-5
Cat. No. CS-0157358
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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3-Chloro-5-(2,2,2-trifluoroethoxy)pyridazine|CS-0157358

Structure of 1346691-33-5

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Description

3-Chloro-5-(2,2,2-trifluoroethoxy)pyridazine is a fluorinated heterocyclic building block featuring a chlorine substituent at the 3-position and a trifluoroethoxy group at the 5-position of the pyridazine core. This combination imparts enhanced electron-withdrawing character and metabolic stability, enabling efficient incorporation into bioactive molecules. The trifluoroethoxy moiety improves lipophilicity and membrane permeability, while the chloro group provides a reactive handle for cross-coupling transformations. This compound serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active agents.

Application

3-Chloro-5-(2,2,2-trifluoroethoxy)pyridazine serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated heterocyclic scaffolds. The trifluoroethoxy group enhances metabolic stability and lipophilicity, while the chloropyridazine core supports palladium-catalyzed cross-coupling reactions. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient synthesis of complex API candidates.

General Information

CAS No. 1346691-33-5
Cat. No. CS-0157358
Purity ≥95%
MDL No. None
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄ClF₃N₂O
Molecular Weight 212.56
Synonym(s) 5-(2,2,2-trifluoroethoxy)-3-chloropyridazine
SMILES C1=C(C=NN=C1Cl)OCC(F)(F)F

Computational Chemistry Data

TPSA 35.01
LogP 2.0711
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Ether

Building Blocks Skeleton Aromatic heterocycle compounds Pyridazine compounds

Key Words

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3-Chloro-5-(2,2,2-trifluoroethoxy)pyridazine

CAS No. 1346691-33-5

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