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CS-W001157 4
Total: USD 88.00

1-Methyl-1H-indazole

  • CAS No. 13436-48-1

  • Cat. No. CS-0054743
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1H-indazole|CS-0054743

Structure of 13436-48-1

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Description

1-Methyl-1H-indazole is a bench-stable, nitrogen-rich heterocycle featuring a fused indole-like core with a methyl group at the pyrrole nitrogen. This substitution enhances solubility and metabolic stability while preserving reactivity at the aromatic ring. The molecule serves as a key pharmacophore in medicinal chemistry, enabling integration into kinase inhibitors and CNS-targeted therapeutics through its ability to form hydrogen bonds and engage in π-stacking interactions.

Application

1-Methyl-1H-indazole serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its methylated nitrogen at the 1-position enhances metabolic stability and modulates basicity, facilitating direct functionalization at C3 or C5 positions. The compound exhibits excellent bench stability, tolerates a range of reaction conditions, and is compatible with common coupling protocols, making it well-suited for parallel synthesis and lead optimization campaigns.

General Information

  • CAS No. 13436-48-1
  • Cat. No. CS-0054743
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₂
  • Molecular Weight 132.16
  • Synonym(s) 1-Methylindazole
  • SMILES CN1N=CC2=CC=CC=C12

Computational Chemistry Data

  • TPSA   17.82
  • LogP   1.5733
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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