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Structure of 13436-48-1
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1-Methyl-1H-indazole is a bench-stable, nitrogen-rich heterocycle featuring a fused indole-like core with a methyl group at the pyrrole nitrogen. This substitution enhances solubility and metabolic stability while preserving reactivity at the aromatic ring. The molecule serves as a key pharmacophore in medicinal chemistry, enabling integration into kinase inhibitors and CNS-targeted therapeutics through its ability to form hydrogen bonds and engage in π-stacking interactions.
1-Methyl-1H-indazole serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its methylated nitrogen at the 1-position enhances metabolic stability and modulates basicity, facilitating direct functionalization at C3 or C5 positions. The compound exhibits excellent bench stability, tolerates a range of reaction conditions, and is compatible with common coupling protocols, making it well-suited for parallel synthesis and lead optimization campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: