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CS-W001157 4
Total: USD 88.00

5-Bromo-3-(trifluoromethyl)benzofuran

  • CAS No. 1341125-78-7

  • Cat. No. CS-0328914
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-(trifluoromethyl)benzofuran|CS-0328914

Structure of 1341125-78-7

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General Information

  • CAS No. 1341125-78-7
  • Cat. No. CS-0328914
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₄BrF₃O
  • Molecular Weight 265.03
  • Synonym(s) None
  • SMILES C1=CC2=C(C=C1Br)C(=CO2)C(F)(F)F

Description

5-Bromo-3-(trifluoromethyl)benzofuran features a bromine substituent and a trifluoromethyl group positioned ortho to each other on the benzofuran core. This electron-deficient scaffold enables direct functionalization in transition-metal-catalyzed cross-coupling reactions, serving as a key building block for bioactive heterocycles and advanced materials.

Application

5-Bromo-3-(trifluoromethyl)benzofuran serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions due to its reactive bromine substituent. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the benzofuran core provides a rigid, planar scaffold suitable for targeted molecular design. Bench-stable and compatible with standard synthetic workflows, it facilitates efficient construction of complex heterocyclic architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   13.14
  • LogP   4.2141
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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