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CS-W001157 4
Total: USD 88.00

Methyl 2,3-dioxoindoline-7-carboxylate

  • CAS No. 103030-10-0

  • Cat. No. CS-0043118
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 2,3-dioxoindoline-7-carboxylate|CS-0043118

Structure of 103030-10-0

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General Information

  • CAS No. 103030-10-0
  • Cat. No. CS-0043118
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇NO₄
  • Molecular Weight 205.17
  • Synonym(s) methyl 2,3-dioxo-2,3-dihydro-1H-indole-7-carboxylate
  • SMILES O=C(C1=CC=CC2=C1NC(C2=O)=O)OC

Description

Methyl 2,3-dioxoindoline-7-carboxylate serves as a key scaffold in heterocyclic synthesis, featuring a fused indoline core with dual carbonyl groups at positions 2 and 3. This electron-deficient system enables efficient functionalization at the C7 position, facilitating coupling reactions under mild conditions. The methyl ester moiety enhances solubility and stability, supporting direct use in multi-step sequences.

Application

Methyl 2,3-dioxoindoline-7-carboxylate serves as a versatile building block for the synthesis of indoline-based heterocycles and bioactive scaffolds. Its ortho-dicarbonyl functionality enables facile cyclization and metal-catalyzed transformations, while the ester group offers compatibility with standard functional group manipulations. Bench-stable and readily purified, it facilitates efficient access to complex architectures in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      2,3-Dioxoindoline-7-carboxylic acid|CS-W021493
      25128-35-2
    • ~94%
    • In-stock
      Methyl 2,3-dioxoindoline-7-carboxylate|CS-0043118
      103030-10-0

    References

    • Synthetic Communications, , vol. 29, # 23 p. 4223 - 4233
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 74, p. 2637,2642 Gazzetta Chimica Italiana, , vol. 83, p. 155,161 Journal fuer Praktische Chemie (Leipzig), , vol. <2> 147, p. 338,340
  • Route3
    • methyl 2-[[2-hydroxyiminoacetyl]amino]benzoate|CS-0037935
      63016-87-5
    • ~%
    • In-stock
      Methyl 2,3-dioxoindoline-7-carboxylate|CS-0043118
      103030-10-0

    References

    • Journal fuer Praktische Chemie (Leipzig), , vol. <2> 147, p. 338,340

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   72.47
  • LogP   0.608
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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