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CS-W001157 4
Total: USD 88.00

5-Bromo-3-(trifluoromethyl)benzofuran

  • CAS No. 1341125-78-7

  • Cat. No. CS-0328914
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-(trifluoromethyl)benzofuran|CS-0328914

Structure of 1341125-78-7

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Description

5-Bromo-3-(trifluoromethyl)benzofuran features a bromine substituent and a trifluoromethyl group positioned ortho to each other on the benzofuran core. This electron-deficient scaffold enables direct functionalization in transition-metal-catalyzed cross-coupling reactions, serving as a key building block for bioactive heterocycles and advanced materials.

Application

5-Bromo-3-(trifluoromethyl)benzofuran serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions due to its reactive bromine substituent. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the benzofuran core provides a rigid, planar scaffold suitable for targeted molecular design. Bench-stable and compatible with standard synthetic workflows, it facilitates efficient construction of complex heterocyclic architectures.

General Information

  • CAS No. 1341125-78-7
  • Cat. No. CS-0328914
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₄BrF₃O
  • Molecular Weight 265.03
  • Synonym(s) None
  • SMILES C1=CC2=C(C=C1Br)C(=CO2)C(F)(F)F

Computational Chemistry Data

  • TPSA   13.14
  • LogP   4.2141
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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