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CS-W001157 4
Total: USD 88.00

N6-(But-2-enoyl)-L-lysine

  • CAS No. 1338823-35-0

  • Cat. No. CS-0100643
  • Molecule weight214.26
  • Purity≥97%
  • MDL No.MFCD22381072

*For research and further manufacturing use only, not for direct human use.

N6-(But-2-enoyl)-L-lysine|CS-0100643

Structure of 1338823-35-0

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General Information

  • CAS No. 1338823-35-0
  • Cat. No. CS-0100643
  • Purity ≥97%
  • MDL No. MFCD22381072
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₈N₂O₃
  • Molecular Weight 214.26
  • Synonym(s) H-Lys(Crotonyl)-Oh
  • SMILES N[C@@H](CCCCNC(/C=C/C)=O)C(O)=O

Description

N6-(But-2-enoyl)-L-lysine features a conjugated enoyl group at the ε-amino position, enabling direct Michael addition reactions. This electrophilic moiety integrates readily into peptide scaffolds and supports bioconjugation workflows under physiological conditions. The molecule exhibits enhanced stability in aqueous environments compared to reactive acylating agents.

Application

N6-(But-2-enoyl)-L-lysine serves as a versatile synthetic intermediate for the construction of bioactive heterocycles and peptide-based scaffolds. Its α,β-unsaturated enamide functionality enables efficient Michael additions and cycloaddition reactions, while the L-lysine backbone provides a readily derivatizable amine handle. Bench-stable and compatible with standard peptide coupling protocols, it facilitates the modular synthesis of complex molecular architectures in medicinal chemistry and chemical biology applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   92.42
  • LogP   0.2609
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   7

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