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CS-W001157 4
Total: USD 88.00

2-Amino-5-bromo-4-methylthiazole hydrochloride

  • CAS No. 133692-16-7

  • Cat. No. CS-W021564
  • Molecule weight229.53
  • Purity≥95%
  • MDL No.MFCD09265523

*For research and further manufacturing use only, not for direct human use.

2-Amino-5-bromo-4-methylthiazole hydrochloride|CS-W021564

Structure of 133692-16-7

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General Information

  • CAS No. 133692-16-7
  • Cat. No. CS-W021564
  • Purity ≥95%
  • MDL No. MFCD09265523
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₆BrClN₂S
  • Molecular Weight 229.53
  • Synonym(s) 5-BroMo-4-Methyl-thiazol-2-ylaMinehydrobroMide
  • SMILES Cl.NC1=NC(=C(S1)Br)C

Description

2-Amino-5-bromo-4-methylthiazole hydrochloride features a brominated thiazole core with amino and methyl substituents, delivering enhanced solubility and stability under standard conditions. This bench-stable derivative enables efficient incorporation into heterocyclic scaffolds for medicinal chemistry applications.

Application

2-Amino-5-bromo-4-methylthiazole hydrochloride serves as a versatile building block in heterocyclic synthesis, enabling efficient access to thiazole-based scaffolds prevalent in medicinal chemistry. Its bromo group facilitates palladium-catalyzed cross-coupling reactions, while the amino functionality supports derivatization via acylation or alkylation. The hydrochloride salt enhances solubility and bench stability, simplifying handling and purification in standard synthetic workflows.

Synthesis

  • Route1

    References

    • Tsuji, Kiyoshi; Ogino, Takashi; Seki, Nobuo; Sawada, Masae; Sudo, Yu; Nishigaki, Fusako; Manda, Toshitaka; Matsuo, Masaaki Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 18 p. 2473 - 2478

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.21802
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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