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CS-W001157 4
Total: USD 88.00

(2-Fluoro-4-(hydroxymethyl)phenyl)boronic acid

  • CAS No. 1331945-14-2

  • Cat. No. CS-0063797
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

(2-Fluoro-4-(hydroxymethyl)phenyl)boronic acid|CS-0063797

Structure of 1331945-14-2

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Description

This boronic acid features a fluorinated aryl ring paired with a hydroxymethyl-bearing boronate group, enabling efficient Suzuki-Miyaura coupling under standard conditions. The ortho-fluoro substituent enhances reactivity and metabolic stability, while the hydroxymethyl handle facilitates downstream functionalization. Bench-stable and moisture-tolerant, it integrates seamlessly into complex molecule synthesis workflows.

Application

(2-Fluoro-4-(hydroxymethyl)phenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. The hydroxymethyl group provides a handle for downstream functionalization, while the boronic acid moiety exhibits excellent bench stability and compatibility with diverse reaction conditions. Its ortho-fluorine substituent enhances reactivity and facilitates selective transformations, making it a practical choice for medicinal chemistry and process development workflows.

General Information

  • CAS No. 1331945-14-2
  • Cat. No. CS-0063797
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BFO₃
  • Molecular Weight 169.95
  • Synonym(s) [2-Fluoro-4-(hydroxyMethyl)phenyl]boronic acid
  • SMILES OCC1=CC=C(B(O)O)C(F)=C1

Computational Chemistry Data

  • TPSA   60.69
  • LogP   -1.0022
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362-P370+P378-P405-P501

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