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CS-W001157 4
Total: USD 88.00

(E)-3-(Thiazol-4-yl)acrylic acid

  • CAS No. 133047-17-3

  • Cat. No. CS-0311605
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(E)-3-(Thiazol-4-yl)acrylic acid|CS-0311605

Structure of 133047-17-3

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General Information

  • CAS No. 133047-17-3
  • Cat. No. CS-0311605
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅NO₂S
  • Molecular Weight 155.17
  • Synonym(s) 3-(1,3-Thiazol-4-yl)prop-2-enoic acid
  • SMILES O=C(O)/C=C/C1=CSC=N1

Description

(E)-3-(Thiazol-4-yl)acrylic acid features a conjugated enoic acid system linked to a thiazole heterocycle, delivering enhanced electronic delocalization and structural rigidity. This configuration supports its role in synthesizing bioactive heterocycles and functional materials, particularly where planar, electron-deficient architectures are required. The compound exhibits stability under standard handling conditions and integrates readily into cross-coupling and cycloaddition workflows.

Application

(E)-3-(Thiazol-4-yl)acrylic acid serves as a versatile building block for the synthesis of thiazole-containing pharmaceuticals and bioactive heterocycles. Its conjugated enoic acid functionality enables efficient Michael additions, Diels-Alder reactions, and palladium-catalyzed coupling processes. The molecule exhibits good bench stability and facilitates straightforward purification via recrystallization, making it well-suited for scalable medicinal chemistry campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.2409
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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