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CS-W001157 4
Total: USD 88.00

6-Isopropoxynicotinaldehyde

  • CAS No. 884495-35-6

  • Cat. No. CS-0043831
  • Purity≥96%
  • MDL No.MFCD07368872

*For research and further manufacturing use only, not for direct human use.

6-Isopropoxynicotinaldehyde|CS-0043831

Structure of 884495-35-6

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General Information

  • CAS No. 884495-35-6
  • Cat. No. CS-0043831
  • Purity ≥96%
  • MDL No. MFCD07368872
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO₂
  • Molecular Weight 165.19
  • Synonym(s) 5-Formyl-2-isopropoxypyridine
  • SMILES O=CC1=CN=C(OC(C)C)C=C1

Description

6-Isopropoxynicotinaldehyde delivers a sterically hindered isopropoxy group at the pyridine ring's 6-position, enhancing solubility and stability under standard conditions. This electron-deficient aldehyde integrates readily into Suzuki-Miyaura coupling protocols and serves as a key intermediate in bioactive heterocycle synthesis.

Application

6-Isopropoxynicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via condensation and coupling reactions. Its isopropoxy group enhances solubility and modulates electronic properties, while the aldehyde functionality offers reliable reactivity for imine formation, Ugi-type multicomponent reactions, and transition-metal-catalyzed transformations. Bench-stable and readily purified by distillation or chromatography, it functions effectively in scalable synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.6813
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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