(5-Chloro-6-methoxypyridin-3-yl)methanol

Name: (5-Chloro-6-methoxypyridin-3-yl)methanol
Brand: ChemScene
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CAS No. 132865-53-3
Cat. No. CS-0173729
Purity≥98%
MDL No.MFCD04972396

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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(5-Chloro-6-methoxypyridin-3-yl)methanol|CS-0173729

Structure of 132865-53-3

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General Information

CAS No. 132865-53-3
Cat. No. CS-0173729
Purity ≥98%
MDL No. MFCD04972396
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₈ClNO₂
Molecular Weight 173.60
Synonym(s) 5-Chloro-6-methylpyridine-3-methanol
SMILES OCC1=CC(Cl)=C(OC)N=C1

Description

(5-Chloro-6-methoxypyridin-3-yl)methanol features a pyridine core functionalized with chlorine and methoxy groups at positions 5 and 6, respectively, and a reactive hydroxymethyl moiety at position 3. This configuration enables direct coupling or derivatization in synthetic workflows requiring electron-deficient heterocyclic scaffolds with orthogonal handles. The molecule exhibits bench-stable behavior under standard conditions and supports efficient integration into medicinal chemistry campaigns targeting kinase inhibitors and bioactive heterocycles.

Application

(5-Chloro-6-methoxypyridin-3-yl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds. Its pendant hydroxymethyl group facilitates derivatization via oxidation, protection, or coupling reactions, while the chloro and methoxy substituents provide orthogonal reactivity for further functionalization. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, making it well-suited for modular synthesis of API candidates and heterocyclic intermediates.

Synthesis

Route1
- In-stock
  
  54127-30-9
- 124-41-4
- ~%
- In-stock
  
  132865-53-3
References
- WO2005/28434 A2, ; Page/Page column 310 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 42.35
LogP 1.2359
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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(5-Chloro-6-methoxypyridin-3-yl)methanol

CAS No. 132865-53-3

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