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CS-W001157 4
Total: USD 88.00

4-Bromo-3,5-dimethylphenol

  • CAS No. 7463-51-6

  • Cat. No. CS-0012425
  • Purity≥98%
  • MDL No.MFCD00002315

*For research and further manufacturing use only, not for direct human use.

4-Bromo-3,5-dimethylphenol|CS-0012425

Structure of 7463-51-6

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General Information

  • CAS No. 7463-51-6
  • Cat. No. CS-0012425
  • Purity ≥98%
  • MDL No. MFCD00002315
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉BrO
  • Molecular Weight 201.06
  • Synonym(s) 4-Bromo-3,5-xylenol; 4-Bromo-3,5-dimethylphenol
  • SMILES OC1=CC(C)=C(Br)C(C)=C1

Description

4-Bromo-3,5-dimethylphenol offers a sterically hindered phenolic scaffold with enhanced solubility and stability. The bromine at the para position enables efficient cross-coupling reactions, while the two methyl groups confer electron-donating character and resistance to oxidation. This compound serves as a key building block in pharmaceutical intermediates and functional materials synthesis.

Application

4-Bromo-3,5-dimethylphenol serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted aromatic systems via palladium-catalyzed cross-coupling reactions. Its ortho-directed bromine and methyl-substituted phenolic core provide excellent functional group tolerance and bench stability, facilitating straightforward purification and integration into complex molecular architectures common in agrochemical and pharmaceutical research.

Synthesis

  • Route1
    • null|null
      108-68-9
    • ~93%
    • In-stock
      4-Bromo-3,5-dimethylphenol|CS-0012425
      7463-51-6

    References

    • Zysman-Colman, Eli; Arias, Karla; Siegel, Jay S. Canadian Journal of Chemistry, 2009 , vol. 87, # 2 p. 440 - 447
  • Route2
    • null|null
      108-68-9
    • ~71%
    • In-stock
      4-Bromo-3,5-dimethylphenol|CS-0012425
      7463-51-6
    • 2,4-Dibromo-3,5-dimethylphenol|CS-0875466
      38730-39-1

    References

    • Journal of Chemical Research, Synopses, , # 6 p. 244 - 245
  • Route3
    • null|null
      93684-16-3
    • ~%
    • In-stock
      4-Bromo-3,5-dimethylphenol|CS-0012425
      7463-51-6

    References

    • Journal of the American Chemical Society, , vol. 107, # 2 p. 455 - 459

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.77154
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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