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CS-W001157 4
Total: USD 88.00

N-Boc-Cyclopropylamine

  • CAS No. 132844-48-5

  • Cat. No. CS-W000437
  • Purity≥95%
  • MDL No.MFCD09701238

*For research and further manufacturing use only, not for direct human use.

N-Boc-Cyclopropylamine|CS-W000437

Structure of 132844-48-5

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General Information

  • CAS No. 132844-48-5
  • Cat. No. CS-W000437
  • Purity ≥95%
  • MDL No. MFCD09701238
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₅NO₂
  • Molecular Weight 157.21
  • Synonym(s) tert-butyl cyclopropylcarbamatato
  • SMILES O=C(OC(C)(C)C)NC1CC1

Description

N-Boc-Cyclopropylamine features a cyclopropyl ring tethered to a nitrogen atom bearing a bulky Boc protecting group. This configuration enhances stability and solubility in organic media, enabling reliable incorporation into peptide conjugates and small-molecule scaffolds under standard conditions.

Application

N-Boc-Cyclopropylamine serves as a stable, bench-ready building block for the incorporation of cyclopropylamine moieties into complex molecules. The Boc group provides excellent protection of the amine, enabling orthogonal functionalization and compatibility with diverse reaction conditions. It facilitates efficient cyclizations, coupling reactions, and transition-metal-catalyzed transformations, making it valuable in medicinal chemistry and API synthesis.

Synthesis

  • Route1
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • null|null
      765-30-0
    • ~97%
    • In-stock
      N-Boc-Cyclopropylamine|CS-W000437
      132844-48-5

    References

    • Tars, Kaspars; Leitans, Janis; Kazaks, Andris; Zelencova, Diana; Liepinsh, Edgars; Kuka, Janis; Makrecka, Marina; Lola, Daina; Andrianovs, Viktors; Gustina, Daina; Grinberga, Solveiga; Liepinsh, Edvards; Kalvinsh, Ivars; Dambrova, Maija; Loza, Einars; Pugovics, Osvalds Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2213 - 2236
  • Route2
    • null|null
      75-65-0
    • In-stock
      Cyclopropanecarboxylic acid Olaparib Impurity|CS-0167593
      1759-53-1
    • ~79%
    • In-stock
      N-Boc-Cyclopropylamine|CS-W000437
      132844-48-5

    References

    • Kuttab, Simon; Mabic, Stephan Journal of Labelled Compounds and Radiopharmaceuticals, 2002 , vol. 45, # 10 p. 813 - 822

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   1.6735
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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