N-Cyclopropyl-4-methylbenzenesulfonamide

Name: N-Cyclopropyl-4-methylbenzenesulfonamide
Brand: ChemScene
Availability: InStock
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CAS No. 65032-46-4
Cat. No. CS-0163611
Molecule weight211.28
Purity≥98%
MDL No.MFCD00551293

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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N-Cyclopropyl-4-methylbenzenesulfonamide|CS-0163611

Structure of 65032-46-4

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General Information

CAS No. 65032-46-4
Cat. No. CS-0163611
Purity ≥98%
MDL No. MFCD00551293
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₃NO₂S
Molecular Weight 211.28
Synonym(s) None
SMILES O=S(C1=CC=C(C)C=C1)(NC2CC2)=O

Description

N-Cyclopropyl-4-methylbenzenesulfonamide features a cyclopropyl group attached to the sulfonamide nitrogen, enhancing metabolic stability and lipophilicity. The para-methyl aryl sulfonamide scaffold provides robust electron donation and steric resilience. This compound integrates readily into bioactive scaffolds for kinase inhibition and medicinal chemistry screening under standard conditions.

Application

N-Cyclopropyl-4-methylbenzenesulfonamide serves as a stable, bench-ready sulfonamide building block for medicinal chemistry and process development. Its cyclopropyl amine moiety provides favorable metabolic stability and enhanced membrane permeability, while the para-methylbenzenesulfonamide group offers robust functional group tolerance and ease of purification. The compound facilitates diverse transformations in late-stage functionalization and enables efficient construction of biologically relevant heterocyclic scaffolds through standard coupling protocols.

Synthesis

Route1
- 98-59-9
- 765-30-0
- ~85%
- In-stock
  
  65032-46-4
References
- O'Sullivan, Steven; Doni, Eswararao; Tuttle, Tell; Murphy, John A. Angewandte Chemie - International Edition, 2014 , vol. 53, # 2 p. 474 - 478 Angew. Chem., 2013 , vol. 126, # 2 p. 484 - 488,5

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 46.17
LogP 1.43572
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 3

Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

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N-Cyclopropyl-4-methylbenzenesulfonamide

CAS No. 65032-46-4

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