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CS-W001157 4
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Methyl 2-amino-2-methylpropanoate

  • CAS No. 13257-67-5

  • Cat. No. CS-0006965
  • Purity≥98%
  • MDL No.MFCD12407415

*For research and further manufacturing use only, not for direct human use.

Methyl 2-amino-2-methylpropanoate|CS-0006965

Structure of 13257-67-5

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General Information

  • CAS No. 13257-67-5
  • Cat. No. CS-0006965
  • Purity ≥98%
  • MDL No. MFCD12407415
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁NO₂
  • Molecular Weight 117.15
  • Synonym(s) α-methylalanine methyl ester
  • SMILES NC(C)(C(OC)=O)C

Description

Methyl 2-amino-2-methylpropanoate is a bench-stable, moisture-tolerant amino acid derivative featuring a tertiary α-carbon. This sterically hindered structure enhances stability and facilitates selective coupling reactions in peptide synthesis. The methyl ester group enables straightforward derivatization, while the pendant amine supports further functionalization. A valuable building block for bioactive molecule construction.

Application

Methyl 2-amino-2-methylpropanoate serves as a valuable building block in peptide and heterocyclic synthesis, offering a sterically hindered α-amino ester with high bench stability and ease of purification. Its tertiary α-carbon minimizes racemization during coupling reactions, while the amino group enables straightforward derivatization for scaffold diversification. This compound functions effectively in standard amide bond formation protocols and supports the construction of medicinally relevant motifs.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2924
Class : 3,8
Packing Group : Ⅲ
Hazard Statements : H225-H314
Precautionary Statements : P210-P240-P241-P280-P370+P378

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   -0.1033
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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