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CS-W001157 4
Total: USD 88.00

Duloxetine impurity 10

  • CAS No. 132335-44-5

  • Cat. No. CS-W023104
  • Purity≥97%
  • MDL No.MFCD07782107

*For research and further manufacturing use only, not for direct human use.

Duloxetine impurity 10|CS-W023104

Structure of 132335-44-5

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General Information

  • CAS No. 132335-44-5
  • Cat. No. CS-W023104
  • Purity ≥97%
  • MDL No. MFCD07782107
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₅NOS
  • Molecular Weight 185.29
  • Synonym(s) None
  • SMILES CN(C)CC[C@@H](C1=CC=CS1)O

Application

(S)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)-1-propylamine serves as a versatile chiral building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its hydroxyl group enables efficient derivatization via esterification or ether formation, while the thienyl moiety provides a robust aromatic handle for cross-coupling reactions. The molecule exhibits excellent bench stability and functional group tolerance, facilitating straightforward purification and integration into multi-step synthetic sequences.

Synthesis

  • Route1
    • 3-(Dimethylamino)-1-(thiophen-2-yl)propan-1-one|CS-0122596
      13196-35-5
    • ~81%
    • In-stock
      Duloxetine impurity 10|CS-W023104
      132335-44-5

    References

    • Mitsubishi Rayon Co., Ltd. Patent: EP1506965 A1, 2005 ; Location in patent: Page/Page column 35 ;
  • Route2
    • 3-(Dimethylamino)-1-(thiophen-2-yl)propan-1-one hydrochloride Duloxetine Impurity|CS-0228934
      5424-47-5
    • ~%
    • In-stock
      Duloxetine impurity 10|CS-W023104
      132335-44-5

    References

    • US2005/197503 A1, ; Page/Page column 4 ;
  • Route3
    • 3-(Dimethylamino)-1-(thiophen-2-yl)propan-1-one|CS-0122596
      13196-35-5
    • ~67%
    • In-stock
      (R)-3-(Dimethylamino)-1-(thiophen-2-yl)propan-1-ol|CS-0151300
      132335-49-0
    • In-stock
      Duloxetine impurity 10|CS-W023104
      132335-44-5

    References

    • Lonza AG Patent: WO2004/31168 A2, 2004 ; Location in patent: Page 15-16 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   23.47
  • LogP   1.7332
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   4

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