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CS-W001157 4
Total: USD 88.00

3-Bromopyrazolo[1,5-a]pyrimidin-6-ol

  • CAS No. 1314893-97-4

  • Cat. No. CS-0080446
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromopyrazolo[1,5-a]pyrimidin-6-ol|CS-0080446

Structure of 1314893-97-4

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General Information

  • CAS No. 1314893-97-4
  • Cat. No. CS-0080446
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrN₃O
  • Molecular Weight 214.02
  • Synonym(s) 3-Bromo-pyrazolo[1,5-a]pyrimidin-6-ol
  • SMILES BrC1=C2N=CC(O)=CN2N=C1

Description

3-Bromopyrazolo[1,5-a]pyrimidin-6-ol features a brominated pyrazolo[1,5-a]pyrimidine core with a phenolic hydroxyl group, enabling direct functionalization in medicinal chemistry. This scaffold integrates readily into kinase inhibitors and nucleoside analogs due to its planar structure and hydrogen-bonding capacity. The bromine atom serves as a handle for palladium-catalyzed cross-coupling reactions under standard conditions.

Application

3-Bromopyrazolo[1,5-a]pyrimidin-6-ol serves as a versatile heterocyclic building block for medicinal chemistry and catalytic cross-coupling applications. Its bromine substituent enables palladium-catalyzed transformations such as Suzuki-Miyaura and Buchwald-Hartwig couplings, while the pyrimidin-6-ol functionality offers hydrogen-bonding capacity and metabolic stability. The compound exhibits good bench stability and facilitates efficient purification via crystallization or chromatography, making it well-suited for scalable synthesis of kinase inhibitors and other bioactive scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   50.42
  • LogP   1.1974
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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