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Bis-PEG4-PFP ester

  • CAS No. 1314378-12-5

  • Cat. No. CS-0109183
  • Purity≥95%
  • MDL No.MFCD21363293

*For research and further manufacturing use only, not for direct human use.

Bis-PEG4-PFP ester|CS-0109183

Structure of 1314378-12-5

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General Information

  • CAS No. 1314378-12-5
  • Cat. No. CS-0109183
  • Purity ≥95%
  • MDL No. MFCD21363293
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₄H₂₀F₁₀O₈
  • Molecular Weight 626.39
  • Synonym(s) None
  • SMILES O=C(OC1=C(F)C(F)=C(F)C(F)=C1F)CCOCCOCCOCCOCCC(OC2=C(F)C(F)=C(F)C(F)=C2F)=O

Description

Bis-PEG4-PFP ester enables efficient, moisture-tolerant conjugation in aqueous environments. This bifunctional reagent features two PFP ester groups flanked by PEG4 spacers, promoting solubility and reducing aggregation. It facilitates site-specific coupling to primary amines on biomolecules, streamlining the synthesis of bioconjugates for diagnostics and therapeutics.

Application

Bis-PEG4-PFP ester serves as a bifunctional crosslinking agent, enabling efficient conjugation of biomolecules via amine-reactive PFP ester groups. The PEG4 spacer provides enhanced solubility and reduced steric hindrance, facilitating homogeneous coupling in aqueous and organic media. Its stability under ambient conditions and clean reaction profile make it ideal for synthesizing site-specific bioconjugates, peptide–protein hybrids, and functionalized nanoparticles.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   89.52
  • LogP   4.4352
  • H_Acceptors   8
  • H_Donors   0
  • Rotatable_Bonds   17

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