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CS-W001157 4
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N3-PEG2-C2-NHS ester

  • CAS No. 1312309-64-0

  • Cat. No. CS-0105088
  • Purity≥95%
  • MDL No.MFCD20926376

*For research and further manufacturing use only, not for direct human use.

N3-PEG2-C2-NHS ester|CS-0105088

Structure of 1312309-64-0

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General Information

  • CAS No. 1312309-64-0
  • Cat. No. CS-0105088
  • Purity ≥95%
  • MDL No. MFCD20926376
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₆N₄O₆
  • Molecular Weight 300.27
  • Synonym(s) None
  • SMILES O=C(ON1C(CCC1=O)=O)CCOCCOCCN=[N+]=[N-]

Description

N3-PEG2-C2-NHS ester features a short, hydrophilic PEG2 spacer flanked by a reactive NHS ester and a bioorthogonal azide group. This bifunctional reagent enables site-specific conjugation in aqueous environments, combining efficient amine coupling with click-compatible tagging for protein labeling and biomaterial engineering.

Application

N3-PEG2-C2-NHS ester serves as a versatile bifunctional linker for site-specific conjugation in synthetic chemistry. The NHS ester group readily reacts with primary amines under physiological conditions, while the terminal azide enables copper-catalyzed or strain-promoted cycloaddition. This combination facilitates efficient bioconjugation workflows, offering excellent stability, ease of purification, and compatibility with diverse biomolecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   130.9
  • LogP   0.3272
  • H_Acceptors   7
  • H_Donors   0
  • Rotatable_Bonds   10

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