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CS-W001157 4
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1-(5-Fluoropyridin-2-yl)cyclopropanecarboxylic acid

  • CAS No. 1302580-98-8

  • Cat. No. CS-0044922
  • Purity≥96%
  • MDL No.MFCD20646242

*For research and further manufacturing use only, not for direct human use.

1-(5-Fluoropyridin-2-yl)cyclopropanecarboxylic acid|CS-0044922

Structure of 1302580-98-8

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General Information

  • CAS No. 1302580-98-8
  • Cat. No. CS-0044922
  • Purity ≥96%
  • MDL No. MFCD20646242
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈FNO₂
  • Molecular Weight 181.16
  • Synonym(s) 1-(5-Fluoro-2-pyridinyl)cyclopropanecarboxylic acid
  • SMILES O=C(C1(C2=NC=C(F)C=C2)CC1)O

Description

This cyclopropanecarboxylic acid features a 5-fluoropyridin-2-yl substituent, offering enhanced electron-withdrawing character and improved metabolic stability. The strained cyclopropane ring imparts rigidity, facilitating precise spatial orientation in synthetic intermediates. Ideal for medicinal chemistry applications requiring targeted bioavailability and structural precision.

Application

1-(5-Fluoropyridin-2-yl)cyclopropanecarboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. Its cyclopropane carboxylic acid motif offers enhanced metabolic stability and conformational rigidity, while the 5-fluoropyridin-2-yl group provides favorable electronic properties for coupling reactions. The compound exhibits good bench stability, facilitates efficient derivatization via standard amide bond formation, and demonstrates compatibility with diverse functional groups, making it well-suited for high-throughput synthesis campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.3369
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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