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5-Methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

  • CAS No. 17288-36-7

  • Cat. No. CS-0042963
  • Purity≥95%
  • MDL No.MFCD08448208

*For research and further manufacturing use only, not for direct human use.

5-Methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid|CS-0042963

Structure of 17288-36-7

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General Information

  • CAS No. 17288-36-7
  • Cat. No. CS-0042963
  • Purity ≥95%
  • MDL No. MFCD08448208
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂O₃
  • Molecular Weight 192.17
  • Synonym(s) 5-Methoxy-6-azaindole-3-carboxylic acid
  • SMILES COC1=CC2=C(NC(=C2)C(O)=O)C=N1

Description

5-Methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid features a fused heterocyclic core with orthogonal functional groups enabling direct integration into bioactive molecule scaffolds. The methoxy substituent enhances solubility and metabolic stability, while the carboxylic acid moiety provides a versatile handle for amide coupling and derivatization under standard conditions.

Application

5-Methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and materials science applications. Its carboxylic acid functionality enables straightforward derivatization via amide coupling or esterification, while the methoxy group provides moderate electron donation and enhances solubility. The fused pyrrolopyridine core offers structural rigidity and π-conjugation, facilitating integration into bioactive scaffolds and functional polymers. Bench-stable and readily purified by recrystallization, it functions effectively in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   75.21
  • LogP   1.2697
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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