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CS-W001157 4
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(2-(Difluoromethoxy)pyridin-3-yl)boronic acid

  • CAS No. 1300750-50-8

  • Cat. No. CS-W007175
  • Purity≥98%
  • MDL No.MFCD18261901

*For research and further manufacturing use only, not for direct human use.

(2-(Difluoromethoxy)pyridin-3-yl)boronic acid|CS-W007175

Structure of 1300750-50-8

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General Information

  • CAS No. 1300750-50-8
  • Cat. No. CS-W007175
  • Purity ≥98%
  • MDL No. MFCD18261901
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BF₂NO₃
  • Molecular Weight 188.93
  • Synonym(s) 2-(difluoroMethoxy)pyridin-3-ylboronic acid
  • SMILES FC(F)OC1=NC=CC=C1B(O)O

Description

This boronic acid features a difluoromethoxypyridine scaffold, offering enhanced stability and solubility in polar solvents. The electron-deficient pyridine ring facilitates efficient Suzuki-Miyaura coupling under mild conditions, enabling direct functionalization of heteroaromatic systems with high chemoselectivity.

Application

(2-(Difluoromethoxy)pyridin-3-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl architectures. Its difluoromethoxy group imparts enhanced metabolic stability and modulates electronic properties, making it valuable for medicinal chemistry applications. The boronic acid moiety offers excellent bench stability, compatibility with diverse reaction conditions, and straightforward purification, facilitating integration into multi-step synthetic sequences.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   62.58
  • LogP   -0.6372
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   3

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