Lot numbers can be found on the outside label of a product:
tert-Butyl 3-((methylsulfonyl)oxy)piperidine-1-carboxylate
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CAS No. 129888-60-4
- Cat. No. CS-M2447
- Purity≥95%
- MDL No.MFCD07787193
*For research and further manufacturing use only, not for direct human use.
Structure of 129888-60-4
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General Information
- CAS No. 129888-60-4
- Cat. No. CS-M2447
- Purity ≥95%
- MDL No. MFCD07787193
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₂₁NO₅S
- Molecular Weight 279.35
- Synonym(s) N-BOC-3-MESYLOXYPIPERIDINE
- SMILES O=C(N1CC(OS(=O)(C)=O)CCC1)OC(C)(C)C
Description
tert-Butyl 3-((methylsulfonyl)oxy)piperidine-1-carboxylate serves as a stable, bench-ready piperidine scaffold with a latent electrophilic handle. The methylsulfonyloxy group enables efficient displacement reactions under mild conditions, facilitating the introduction of diverse nucleophiles. This reagent integrates seamlessly into synthetic sequences requiring selective functionalization, particularly in medicinal chemistry and process development workflows.
Application
tert-Butyl 3-((methylsulfonyl)oxy)piperidine-1-carboxylate serves as a reliable piperidine-based electrophile for C–H functionalization and late-stage diversification. The methylsulfonyloxy group enables efficient displacement reactions under mild conditions, facilitating the installation of diverse nucleophiles at the C3 position. Its bench-stable nature and compatibility with common protecting groups make it a practical choice for constructing complex heterocyclic scaffolds in medicinal chemistry workflows.
Synthesis
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Route1
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In-stock
85275-45-2 -
124-63-0 - ~99%
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In-stock
129888-60-4
References
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VERTEX PHARMACEUTICALS INCORPORATED; Charrier, Jean-Damien; Durrant, Steven John; Knegtel, Ronald Patent: US2013/115310 A1, 2013 ; Location in patent: Paragraph 0248; 0249 ;
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Route2
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In-stock
85275-45-2
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7143-01-3
- ~90%
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In-stock
129888-60-4
References
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BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; HOPKINS, Brian, T.; SCOTT, Daniel; CONLON, Patrick; JENKINS, Tracy, J.; POWELL, Noel; GUAN, Bing; CURERVO, Julio, H.; WANG, Deping; TAVERAS, Art Patent: WO2012/58645 A1, 2012 ; Location in patent: Page/Page column 210 ; WO 2012/058645 A1
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Route3
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In-stock
85275-45-2
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124-63-0
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121-44-8
- ~94%
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In-stock
129888-60-4
References
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The United States of America as represented by the Department of Health and Human Services Patent: US5571832 A1, 1996 ; US 5571832 A
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 72.91
- LogP 1.3621
- H_Acceptors 5
- H_Donors 0
- Rotatable_Bonds 2
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Key Words
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