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Structure of 453565-90-7
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3-Bromo-5-(trifluoromethoxy)benzoic acid features a trifluoromethoxy group enhancing electron-withdrawal and lipophilicity, while the bromine substituent enables subsequent cross-coupling reactions. This combination delivers a robust platform for medicinal chemistry and materials synthesis under standard conditions.
3-Bromo-5-(trifluoromethoxy)benzoic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its orthogonal functional groups—bromide and carboxylic acid—enable diverse cross-coupling reactions and derivatization strategies, including Suzuki, Stille, and amide formation. The trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, making it valuable in medicinal chemistry campaigns targeting CNS and oncology therapeutics. The compound exhibits good bench stability and is readily purified by recrystallization or chromatography.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: