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CS-W001157 4
Total: USD 88.00

Fmoc-12-aminododecanoic acid

  • CAS No. 128917-74-8

  • Cat. No. CS-0149770
  • Purity≥98%
  • MDL No.MFCD00235888

*For research and further manufacturing use only, not for direct human use.

Fmoc-12-aminododecanoic acid|CS-0149770

Structure of 128917-74-8

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General Information

  • CAS No. 128917-74-8
  • Cat. No. CS-0149770
  • Purity ≥98%
  • MDL No. MFCD00235888
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₇H₃₅NO₄
  • Molecular Weight 437.57
  • Synonym(s) None
  • SMILES O=C(O)CCCCCCCCCCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O

Description

Fmoc-12-aminododecanoic acid features a long aliphatic chain terminated by a primary amine, enabling efficient conjugation in peptide synthesis and polymer functionalization. The Fmoc group provides orthogonal protection for the amine, ensuring selective coupling under standard conditions. This derivative offers enhanced solubility in organic solvents and stability during storage.

Application

Fmoc-12-aminododecanoic acid serves as a versatile bifunctional building block for peptide conjugation and polymer synthesis. The Fmoc group enables efficient, orthogonal protection during solid-phase peptide synthesis, while the terminal primary amine facilitates coupling reactions with carboxylate-bearing molecules. Its long aliphatic chain provides enhanced solubility and reduced aggregation in solution-phase and solid-phase workflows, making it ideal for constructing bioconjugates, PEGylated peptides, and functionalized materials.

Synthesis

  • Route1
    • null|null
      28920-43-6
    • 12-Aminododecanoic acid|CS-0158382
      693-57-2
    • ~89%
    • In-stock
      Fmoc-12-aminododecanoic acid|CS-0149770
      128917-74-8

    References

    • Journal of Organic Chemistry, , vol. 72, # 5 p. 1691 - 1698

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   6.5107
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   14

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