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7-Fluoro-1H-indole-3-carbaldehyde

  • CAS No. 126921-16-2

  • Cat. No. CS-0037102
  • Molecule weight163.15
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Fluoro-1H-indole-3-carbaldehyde|CS-0037102

Structure of 126921-16-2

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General Information

  • CAS No. 126921-16-2
  • Cat. No. CS-0037102
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆FNO
  • Molecular Weight 163.15
  • Synonym(s) 7-fluoro-1H-indol-3-carbaldehyde
  • SMILES C1=CC2=C(C(=C1)F)NC=C2C=O

Description

7-Fluoro-1H-indole-3-carbaldehyde features a fluorinated indole core with an aldehyde handle at the 3-position, enabling direct incorporation into bioactive molecule synthesis. The electron-deficient carbonyl group facilitates nucleophilic addition reactions, while the para-fluorine enhances metabolic stability and modulates electronic properties for medicinal chemistry applications.

Application

7-Fluoro-1H-indole-3-carbaldehyde serves as a versatile building block for the synthesis of biologically active indole derivatives. Its electrophilic aldehyde functionality enables facile imine formation, reductive amination, and coupling reactions under standard conditions. The electron-withdrawing fluorine substituent enhances regioselectivity in subsequent functionalizations and improves metabolic stability in downstream pharmaceutical scaffolds. Bench-stable and compatible with common purification methods, it facilitates efficient access to diverse heterocyclic architectures in medicinal chemistry research.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.86
  • LogP   2.1195
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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