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CS-W001157 4
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7-Fluoro-1H-indole-3-carbonitrile

  • CAS No. 1043601-55-3

  • Cat. No. CS-0377325
  • Purity≥97%
  • MDL No.MFCD12923868

*For research and further manufacturing use only, not for direct human use.

7-Fluoro-1H-indole-3-carbonitrile|CS-0377325

Structure of 1043601-55-3

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General Information

  • CAS No. 1043601-55-3
  • Cat. No. CS-0377325
  • Purity ≥97%
  • MDL No. MFCD12923868
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₅FN₂
  • Molecular Weight 160.15
  • Synonym(s) None
  • SMILES N#CC1=CNC2=C1C=CC=C2F

Description

7-Fluoro-1H-indole-3-carbonitrile features a fluorinated indole core with a nitrile group at the 3-position, enabling direct incorporation into diverse heterocyclic scaffolds. This electron-deficient, bench-stable building block facilitates efficient C–C and C–heteroatom coupling reactions under standard conditions.

Application

7-Fluoro-1H-indole-3-carbonitrile serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted indole scaffolds via standard coupling reactions. The electron-deficient indole core enhances reactivity in nucleophilic substitution and transition-metal-catalyzed transformations. Bench-stable and readily purified, it facilitates the synthesis of pharmaceutically relevant heterocycles with predictable regioselectivity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   39.58
  • LogP   2.17868
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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