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CS-W001157 4
Total: USD 88.00

4-Chloropyrazolo[1,5-a]pyridine-7-carbonitrile

  • CAS No. 1268520-74-6

  • Cat. No. CS-0050887
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Chloropyrazolo[1,5-a]pyridine-7-carbonitrile|CS-0050887

Structure of 1268520-74-6

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General Information

  • CAS No. 1268520-74-6
  • Cat. No. CS-0050887
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄ClN₃
  • Molecular Weight 177.59
  • Synonym(s) None
  • SMILES ClC1=CC=C(C#N)N2N=CC=C12

Description

4-Chloropyrazolo[1,5-a]pyridine-7-carbonitrile features a fused heterocyclic core with complementary electron-withdrawing groups: a chlorine atom at the 4-position and a nitrile function at the 7-position. This combination enhances electrophilicity and facilitates coupling reactions in medicinal chemistry applications. The scaffold exhibits excellent stability under standard bench conditions and integrates readily into bioactive molecule architectures.

Application

4-Chloropyrazolo[1,5-a]pyridine-7-carbonitrile serves as a versatile heterocyclic building block for medicinal chemistry and catalytic synthesis. Its chloro and cyano groups enable directed metalation, Suzuki-Miyaura coupling, and nucleophilic substitution, facilitating the construction of complex pyrazolopyridine scaffolds. The molecule exhibits excellent bench stability and compatibility with standard purification methods, making it well-suited for scalable synthesis and library generation in drug discovery workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   41.09
  • LogP   1.85938
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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