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CS-W001157 4
Total: USD 88.00

4-Bromo-1-isopropyl-1H-imidazole

  • CAS No. 623577-60-6

  • Cat. No. CS-0036631
  • Purity≥97%
  • MDL No.MFCD22372008

*For research and further manufacturing use only, not for direct human use.

4-Bromo-1-isopropyl-1H-imidazole|CS-0036631

Structure of 623577-60-6

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General Information

  • CAS No. 623577-60-6
  • Cat. No. CS-0036631
  • Purity ≥97%
  • MDL No. MFCD22372008
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉BrN₂
  • Molecular Weight 189.05
  • Synonym(s) 4-BroMo-1-(iso-propyl)-1H-iMidazole
  • SMILES CC(C)N1C=C(Br)N=C1

Description

4-Bromo-1-isopropyl-1H-imidazole is a sterically hindered imidazole derivative featuring a bromine atom at the 4-position and an isopropyl group at nitrogen-1. This combination imparts enhanced stability and favorable solubility in organic solvents, enabling its use as a modular building block in transition metal-catalyzed couplings and medicinal chemistry scaffolds.

Application

4-Bromo-1-isopropyl-1H-imidazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of biaryl and heteroaryl scaffolds. The bromine atom facilitates efficient C–C bond formation under standard Suzuki-Miyaura and Stille conditions, while the isopropyl group provides steric and electronic modulation. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for iterative synthesis workflows in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   17.82
  • LogP   2.2265
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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