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CS-W001157 4
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4-Chloro-5-methyl-1H-pyrrolo[2,3-b]pyridine

  • CAS No. 1020056-56-7

  • Cat. No. CS-0037735
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Chloro-5-methyl-1H-pyrrolo[2,3-b]pyridine|CS-0037735

Structure of 1020056-56-7

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General Information

  • CAS No. 1020056-56-7
  • Cat. No. CS-0037735
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇ClN₂
  • Molecular Weight 166.61
  • Synonym(s) None
  • SMILES CC1=CNC2=NC=CC2=C1Cl

Description

4-Chloro-5-methyl-1H-pyrrolo[2,3-b]pyridine is a heteroaromatic scaffold featuring a chlorine substituent at the 4-position and a methyl group at the 5-position, conferring enhanced electron-withdrawing character and improved solubility. This robust core integrates readily into medicinal chemistry libraries, enabling efficient access to kinase inhibitors and targeted therapeutics through Suzuki-Miyaura coupling and other cross-coupling protocols under standard conditions.

Application

4-Chloro-5-methyl-1H-pyrrolo[2,3-b]pyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient construction of kinase inhibitors and other bioactive scaffolds. Its defined regiochemistry and compatibility with palladium-catalyzed cross-coupling reactions facilitate rapid diversification. The chloro group provides a reliable handle for nucleophilic substitution, while the methyl substituent enhances metabolic stability and modulates electronic properties. Bench-stable and readily purified, it functions effectively in standard synthetic workflows for API development.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P305+P351+P338-P330-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.47632
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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