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CS-W001157 4
Total: USD 88.00

(2,3-Difluoro-4-hydroxyphenyl)boronicacid

  • CAS No. 1261169-72-5

  • Cat. No. CS-W020399
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(2,3-Difluoro-4-hydroxyphenyl)boronicacid|CS-W020399

Structure of 1261169-72-5

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General Information

  • CAS No. 1261169-72-5
  • Cat. No. CS-W020399
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BF₂O₃
  • Molecular Weight 173.91
  • Synonym(s) (2,3-Difluoro-4-hydroxyphenyl)boronic acid
  • SMILES OC1=CC=C(C(F)=C1F)B(O)O

Description

(2,3-Difluoro-4-hydroxyphenyl)boronic acid features a hydroxyl group flanked by two fluorine atoms on the aromatic ring, enhancing its electron-deficient character and stability. This configuration enables efficient Suzuki-Miyaura coupling under standard conditions, delivering arylated products with high fidelity. The boronic acid moiety is bench-stable and moisture-tolerant, simplifying handling in synthetic workflows.

Application

(2,3-Difluoro-4-hydroxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of fluorinated biaryls and heterocyclic scaffolds. The ortho-difluoro substitution enhances metabolic stability and modulates electronic properties, while the boronic acid group offers excellent bench stability and compatibility with aqueous workups. Its utility in medicinal chemistry is supported by predictable reactivity and straightforward purification, making it a reliable reagent for target-oriented synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -0.6498
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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