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3-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride

  • CAS No. 1260879-95-5

  • Cat. No. CS-0012649
  • Purity≥98%
  • MDL No.MFCD16659707

*For research and further manufacturing use only, not for direct human use.

3-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride|CS-0012649

Structure of 1260879-95-5

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General Information

  • CAS No. 1260879-95-5
  • Cat. No. CS-0012649
  • Purity ≥98%
  • MDL No. MFCD16659707
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀Cl₂N₂
  • Molecular Weight 205.09
  • Synonym(s) None
  • SMILES ClC1=CC2=C(N=C1)CCNC2.[H]Cl

Description

This tetrahydro-1,6-naphthyridine derivative features a chlorinated aromatic ring system with enhanced solubility and stability under standard conditions. The hydrochloride salt form ensures excellent crystallinity and ease of handling, making it ideal for synthetic applications in medicinal chemistry and process development workflows.

Application

3-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocyclic scaffolds. The tetrahydro-1,6-naphthyridine core exhibits favorable functional group tolerance and bench stability, facilitating downstream transformations such as Suzuki-Miyaura coupling and nucleophilic substitution. Its hydrochloride salt form enhances solubility and handling, supporting scalable synthesis and purification workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   1.8025
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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