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CS-W001157 4
Total: USD 88.00

5,6,7,8-Tetrahydro-1,6-naphthyridine hydrochloride

  • CAS No. 1187830-51-8

  • Cat. No. CS-W000461
  • Purity≥98%
  • MDL No.MFCD11846187

*For research and further manufacturing use only, not for direct human use.

5,6,7,8-Tetrahydro-1,6-naphthyridine hydrochloride|CS-W000461

Structure of 1187830-51-8

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General Information

  • CAS No. 1187830-51-8
  • Cat. No. CS-W000461
  • Purity ≥98%
  • MDL No. MFCD11846187
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁ClN₂
  • Molecular Weight 170.64
  • Synonym(s) 5,6,7,8-Tetrahydro-1,6-naphthyridinehydrochloride
  • SMILES C12=C(N=CC=C2)CCNC1.Cl

Description

5,6,7,8-Tetrahydro-1,6-naphthyridine hydrochloride delivers a rigid, electron-rich heterocyclic scaffold with enhanced solubility and stability under standard conditions. This bench-stable salt form facilitates efficient incorporation into medicinal chemistry campaigns, particularly for targeting kinase enzymes and GPCR receptors through defined hydrogen-bonding interactions.

Application

5,6,7,8-Tetrahydro-1,6-naphthyridine hydrochloride serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its saturated pyridine ring system exhibits favorable solubility and stability under standard synthetic conditions. The hydrochloride salt form enhances crystallinity and handling ease, facilitating purification and incorporation into diverse coupling reactions. Functions effectively as a nitrogen-containing core in the synthesis of kinase inhibitors and other pharmacologically relevant compounds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   1.1491
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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