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3-Bromo-2-(trifluoromethyl)imidazo[1,2-b]pyridazine

  • CAS No. 1260817-66-0

  • Cat. No. CS-0041308
  • Molecule weight266.02
  • Purity≥96%
  • MDL No.MFCD13193556

*For research and further manufacturing use only, not for direct human use.

3-Bromo-2-(trifluoromethyl)imidazo[1,2-b]pyridazine|CS-0041308

Structure of 1260817-66-0

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General Information

  • CAS No. 1260817-66-0
  • Cat. No. CS-0041308
  • Purity ≥96%
  • MDL No. MFCD13193556
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃BrF₃N₃
  • Molecular Weight 266.02
  • Synonym(s) ZNTPSRMZXHASPS-UHFFFAOYSA-N
  • SMILES FC(C1=C(Br)N2N=CC=CC2=N1)(F)F

Description

3-Bromo-2-(trifluoromethyl)imidazo[1,2-b]pyridazine features a trifluoromethyl group that enhances electron deficiency and metabolic stability, while the bromine atom provides a reactive handle for cross-coupling transformations. This scaffold integrates readily into complex heterocyclic architectures used in medicinal chemistry and agrochemical development.

Application

3-Bromo-2-(trifluoromethyl)imidazo[1,2-b]pyridazine serves as a versatile building block for constructing biologically active heterocycles. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the bromo substituent enables palladium-catalyzed cross-coupling reactions. This compound exhibits bench stability and facilitates efficient functionalization in late-stage diversification, making it valuable for medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   30.19
  • LogP   2.5106
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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