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CS-W001157 4
Total: USD 88.00

2-(5-Bromopyridin-2-yl)ethanol

  • CAS No. 1206968-77-5

  • Cat. No. CS-0052265
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(5-Bromopyridin-2-yl)ethanol|CS-0052265

Structure of 1206968-77-5

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General Information

  • CAS No. 1206968-77-5
  • Cat. No. CS-0052265
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BrNO
  • Molecular Weight 202.05
  • Synonym(s) 5-BroMopyridine-2-ethanol
  • SMILES OCCC1=CC=C(Br)C=N1

Description

2-(5-Bromopyridin-2-yl)ethanol features a brominated pyridine ring linked via an ethylene tether, enabling direct incorporation into cross-coupling and functionalization workflows. The pendant hydroxyl group offers a handle for derivatization, while the electron-deficient heterocycle enhances reactivity in palladium-catalyzed transformations. This bench-stable reagent integrates efficiently into synthetic sequences requiring halogenated aromatic motifs.

Application

2-(5-Bromopyridin-yl)ethanol serves as a versatile building block in medicinal chemistry, enabling direct functionalization of pyridine cores via nucleophilic substitution or cross-coupling reactions. Its bromo group facilitates Pd-catalyzed transformations, while the terminal hydroxyl group offers straightforward derivatization for conjugation or protection. The molecule exhibits good bench stability and is compatible with standard purification protocols, making it a reliable reagent for constructing complex heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1

    References

    • Nippon Chemiphar Co., Ltd. Patent: EP2311822 A1, 2011 ; Location in patent: Page/Page column 51 ;
  • Route2
    • In-stock
      5-Bromo-2-methylpyridine|CS-W019938
      3430-13-5
    • null|null
      68-12-2
    • ~86%
    • In-stock
      2-(5-Bromopyridin-2-yl)ethanol|CS-0052265
      1206968-77-5

    References

    • Janssen Pharmaceutica NV Patent: US2012/329792 A1, 2012 ; Location in patent: Page/Page column 43 ;
  • Route3
    • In-stock
      2,5-Dibromopyridine|CS-W001991
      624-28-2
    • null|null
      24850-33-7
    • ~%
    • In-stock
      2-(5-Bromopyridin-2-yl)ethanol|CS-0052265
      1206968-77-5

    References

    • MERCK and CO., INC. Patent: WO2005/26128 A1, 2005 ; Location in patent: Page/Page column 36-37 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.3789
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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